What is Uroxatral (Alfuzosin)?

Alfuzosin is in a group of drugs called alpha-adrenergic (AL-fa ad-ren-ER-jik) blockers. Alfuzosin relaxes the muscles in the prostate and bladder neck, making it easier to urinate.

Alfuzosin is used to improve urination in men with benign prostatic hyperplasia (enlarged prostate).

Alfuzosin may also be used for other purposes not listed in this medication guide.

What is the most important information I should Tadapox know about Uroxatral (Alfuzosin)?

You should not use alfuzosin if you are allergic to it, if you have severe liver disease, or if you are also using ketoconazole (Nizoral), itraconazole (Sporanox), or ritonavir (Norvir). Do not take alfuzosin with other similar medicines such as doxazosin (Cardura), prazosin (Minipress), silodosin (Rapaflo), tamsulosin (Flomax), or terazosin (Hytrin).

Alfuzosin may cause dizziness or fainting. Be careful if you drive or do anything that requires you to be alert. Avoid standing for long periods of time or becoming overheated during exercise and in hot weather. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Alfuzosin can affect your pupils during cataract surgery. Tell your eye surgeon ahead of time that you are using this medication. Do not stop using alfuzosin before surgery unless your surgeon tells you to.

There are many other drugs that can interact with alfuzosin. Tell your doctor about all medications you use.

What should I discuss with my healthcare provider before taking Uroxatral (Alfuzosin)?

You should not use alfuzosin if you are allergic to it, or if you have:

• severe liver disease
• if you are also taking similar medicines such as doxazosin (Cardura), prazosin (Minipress), silodosin (Rapaflo), tamsulosin (Flomax), or terazosin (Hytrin); or
• if you are also using ketoconazole (Nizoral), itraconazole (Sporanox), or ritonavir (Norvir)

If you have any of these other conditions, you may need an alfuzosin dose adjustment or special tests:

• prostate cancer
• liver disease
• kidney disease
• a personal or family history of Long QT syndrome
• angina (chest pain)
• coronary artery disease (hardened arteries)
• a history of low blood pressure (even when caused by taking medications); or
• if you are taking certain medicines to treat HIV or AIDS

Alfuzosin can affect your pupils during cataract surgery. Tell your eye surgeon ahead of time that you are using this medication. Do not stop using alfuzosin before surgery unless your surgeon tells you to.

Although this medication is not for use in women, alfuzosin is not expected to harm an unborn baby. If you are a woman using this medication, tell your doctor if you are pregnant or breast-feeding.

Alfuzosin is not for use in children.

What are the possible side effects of Uroxatral (Alfuzosin)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using alfuzosin and call your doctor at once if you have a serious side effect such as:

• new or worsening chest pain
• nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes)
• feeling like you might pass out; or
• penis erection that is painful or lasts 4 hours or longer

Less serious side effects may include:

• mild dizziness
• headache
• tired feeling; or
• cold symptoms such as stuffy nose, sneezing, sore throat

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.